Sr. Staff Product Manager

About the Role The Sr. Staff Product Manager will lead a complex, multi-year platform program within Illumina’s high-throughput sequencing portfolio, translating customer workflows and technology capabilities into a clear product strategy and requirements. This role partners with R&D, Operations, Commercial, and strategic partners to drive next-phase platform innovations with a customer-first focus and applicability beyond the sequencer.

What You'll Do

• Provide product leadership for a complex, multi-year platform program, including business case framing, customer and market analysis, requirements definition, and strategic decision support.
• Lead market input to design decisions by understanding workflow needs, application requirements, competitive trends, and ecosystem dynamics (library prep, automation, informatics).
• Represent the customer as a critical member of the development core team, by advocating for their needs and ensuring trade off decisions do not impact Illumina’s ability to serve our customers.
• Engage directly with high-throughput customers—genome centers, clinical labs, research institutes, and service providers—to bring a deep, workflow-informed voice of customer into product strategy and development.
• Anchor product decisions in a customer-first understanding of operational constraints, workflow bottlenecks, application needs, and adoption drivers.
• Partner closely with R&D teams to translate customer needs and workflow insights into clear, testable product requirements and acceptance criteria.
• Drive cross-functional execution across chemistry, hardware, software, operations, and commercial stakeholders to ensure program alignment and readiness.
• Support cross-functional teams in modeling adoption patterns, sequencing volume drivers, workflow considerations, and platform economics to inform platform and portfolio decisions.
• Collaborate with Regional Marketing, Product Management, and the Commercial Organization to align on messaging, positioning, launch plans, and customer engagement strategies.
• Develop clear materials and frameworks to support executive decision-making, including product trade-offs, opportunity assessments, and roadmap recommendations.
• Work with commercial teams to create and deliver sales tools, positioning guidance, objection handling, and customer-facing content.
• Build strong relationships with internal and external partners, key opinion leaders, and ecosystem stakeholders to stay ahead of emerging customer and technology trends.
• Represent the platform strategy across internal teams and drive clarity on product direction, customer value, and business impact.

What We're Looking For

• Typically requires a minimum of 12 years of related experience with a Bachelor's degree; or 12 years and a Master's degree; or a PhD with 8 years of experience; or equivalent experience.
• Strong technical knowledge of NGS platforms, workflows, and high-throughput sequencing applications.
• Demonstrated ability to integrate customer insights, technical constraints, and business drivers into clear product strategy and requirements.
• Demonstrated ability to operate as a customer-first product leader, grounding product decisions in real customer workflows, technical realities, and long-term adoption dynamics.
• Experience working in highly cross-functional, matrixed environments with R&D, Operations, Finance, and Commercial teams.
• Proven analytical strength, with the ability to interpret complex data, model businesses cases and link analysis to strategic decisions.
• Strong communication and executive-level presentation skills.
• Experience supporting or launching products in clinical genomics, high-throughput research, or sequencing operations is highly desirable.
• Demonstrated understanding of ecosystem dependencies (workflow integration, automation, informatics, sample logistics) and how they influence customer adoption.
• Up to 30% travel may be required.
• The estimated base salary range for the Sr. Staff Product Manager role based in the United States of America is: $155,600 - $233,400. Should the level or location of the role change during the hiring process, the applicable base pay range may be updated accordingly. The range reflects long‑term growth in the role; therefore, most candidates are hired between the minimum and middle of the range. Placement depends on experience, skills, location, and internal equity. Additionally, all employees are eligible for one of our variable cash programs (bonus or commission) and eligible roles may receive equity as part of the compensation package. We offer a wide range of benefits as innovative as our work, including

Nice to Have

• Experience supporting or launching products in clinical genomics, high-throughput research, or sequencing operations is highly desirable.

Compensation & Benefits

• Salary: USD 155,600 - 233,400 per year.
• Eligibility for variable cash programs (bonus or commission) and potential equity as part of the compensation package.
• A wide range of benefits as innovative as our work.