About this role
About the Role Join Amgen’s Predictive Biology team to develop and validate biologically relevant models of human tissue using induced pluripotent stem cell (iPSC) or primary human tissue. A key focus will be validating tissue architecture, cellular composition, differentiation state, maturation, and functional relevance to ensure models are suitable for discovery and translational research. What You'll Do
- Develop human stem cell-derived models that represent tissue biology and enable disease-versus-normal comparisons.
- Differentiate stem cells into diverse tissue-relevant cell types.
- Build complex model systems, including organoids, assembloids, co-cultures, matrix-supported cultures, or other multicellular tissue-like systems.
- Optimize culture conditions, media composition, growth factor cues, extracellular matrix conditions, differentiation timing, and co-culture parameters.
- Validate model fidelity using readouts of cell identity, tissue architecture, maturation, and tissue-specific function.
- Document protocols, experimental designs, model validation data, and decision criteria in a clear and reproducible manner.
- Communicate results, limitations, and technical risks to cross-functional teams through written reports and oral presentations. What We're Looking For
- PhD in a related discipline with 2+ years of experience, or MSc with related experience.
- Experience with differentiation of stem cells, iPSC-based tissue models, and validation of tissue architecture and function.
- Strong experimental design, data analysis, and documentation skills; ability to clearly communicate results and risk to cross-functional teams.