Senior Scientist, siRNA Pipeline Development, Ex-hepatic

Senior Scientist, siRNA Pipeline Development, Ex-hepatic

Cambridge, MA

Function:

Research & Development

Work location type:

On-Site

Job Type:

Full-time

Job ID:

R00151323

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Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

At AbbVie, we are dedicated to solving some of the world’s most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care.

AbbVie is looking for a Senior Scientist I/II to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics and to enable siRNA delivery for extrahepatic pipeline development. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies.

Responsibilities

• Lead research efforts within a cross-functional team to advance siRNA therapeutics development for ex-hepatic pipelines
• Design, evaluate, and develop novel ex-hepatic siRNA delivery platforms for targeted delivery to tissues of interest
• Conceive and execute proof-of-concept experiments to validate scientific hypotheses and address technical challenges with high-quality results.
• Develop in vitro, ex vivo, and in vivo assays to assess siRNA candidates and delivery technologies in support of program objectives.
• Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor.
• Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions.
• Acquire deep knowledge of RNA biology and siRNA therapeutics to support programs across multiple stages of development.
• Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization.
• Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications.
• Mentor and support junior scientists within the team.

Qualifications

• BS, MS, or PhD in molecular biology, RNA biology, cell biology, pharmaceutical sciences, biomedical engineering, or or a related scientific discipline, with typically 0-4+ (PhD), 8-10+ (MS), or 10-12+ (BS) years of relevant experience.

• Hands-on experience in designing and executing in vitro and in vivo studies to evaluate siRNA delivery platforms, including assessments of cellular uptake, target knockdown, delivery efficiency and biodistribution.

• Demonstrated expertise in siRNA therapeutics, including the design, development, characterization and optimization of siRNA sequences and delivery systems.

• Proven experience with siRNA and antibody-oligo-conjugates (AOCs) is highly desirable.

• Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS), protein quantification (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification.

• Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput.

• Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment.

• Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation.

• Why AbbVie?

• AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine.