Senior Scientist - Experimental Protein Design for Target Discovery

About the Role

Senior Scientist – Experimental Protein Design for Target Discovery role at Amgen focuses on building and leading high-throughput platforms for generating protein binders and translating computational designs into experimentally validated minibinders and antibodies across pre-discovery targets. The role emphasizes production, validation, and characterization of de novo binders and creating scalable libraries for multiplexed screening to accelerate early-stage therapeutic discovery. What You'll Do

• Translate computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.

• Lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder–target evaluation.

• Partner with molecular biology teams to establish construct generation and binder library production workflows, enabling both individual binder characterization and scalable pooled library screening.

• Develop strategies to format de novo binders into appropriate formats for downstream applications.

• Create scalable binder libraries for multiplexed phenotypic screening, developing multispecific tool molecules to interrogate novel biology and providing tool reagents for early-stage target characterization. What We're Looking For

• Experience translating computational protein designs into experimentally testable minibinders and antibodies across multiple targets in parallel.

• Demonstrated ability to lead high-throughput workflows for binder expression, purification, and characterization, including development of cellular assays for binder–target evaluation.

• Collaborative experience with molecular biology teams to establish construct generation and binder library production workflows.

• Ability to develop strategies to format de novo binders into appropriate formats for downstream applications.