Senior Research Associate, Preclinical Pharmacology

Senior Research Associate, Preclinical Pharmacology

Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work.

Position Description

The Opportunity

• Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology

• Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection

• Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads

• Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly

• Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses

• Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation

• Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues

• Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation

• Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings

• Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays

• Adhere to IACUC protocols, animal welfare regulations, and laboratory safety requirements, and maintain required training and certifications

• Contribute to the optimization and qualification of new models and assays and to the training of junior team members

• Maintain laboratory equipment and supplies and support vivarium coordination, including occasional weekend or off-shift study coverage; other essential duties as assigned; minimal travel (