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Senior Manager, Portfolio Analytics & Strategy

Amgen
Thousand Oaks, CA; Los Angeles, CA Posted Aug 13, 2026
Remote

About this role

Senior Manager, Portfolio Analytics & Strategy

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas – Oncology, Inflammation, General Medicine, and Rare Disease – we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

SENIOR MANAGER, PORTFOLIO ANALYTICS & STRATEGY

What you will do

Let’s do this. Let’s change the world. In this vital role you will lead portfolio analysis, performance tracking, and benchmarking, while owning Amgen’s Probability of Technical and Regulatory Success (PTRS) process across the R&D portfolio.

You will serve as a strategic thought partner to Product Teams, Therapeutic Area and Portfolio Governance, translating development risks, evidence, and uncertainty into decision-ready options. You will also oversee technology initiatives that enable PTRS and broader portfolio decision support, working closely with the Technology, Research, and Development organizations, Product Teams, and other cross-functional partners

Key Responsibilities

  • PTRS assessment, strategy, governance, tools & technology

  • Lead and facilitate the enterprise PTRS assessment process with Product Teams and cross-functional experts at key development, investment, and governance milestones.

  • Own and continuously evolve the PTRS methodology, standards, benchmarks, guardrails, governance cadence, and documentation, including integration with portfolio and business-case processes.

  • Oversee development of new PTRS and risk-assessment tools with the Technology organization and functional experts, including data products, evidence workflows, dashboards, and decision-support capabilities.

  • Product Team partnership & decision support

  • Partner with Product Teams to assess risk across alternative target product profiles, indication

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