Senior Director, Small Molecule Drug Discovery in Inflammation

Senior Director, Small Molecule Drug Discovery in Inflammation

remote type On Site

locations US - California - South San Francisco

time type Full time

posted on Posted Yesterday

job requisition id R-250815

Career Category Scientific

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Senior Director, Small Molecule Drug Discovery in Inflammation Discovery

What you will do

Let’s do this. Let’s change the world. In this vital role you will lead early discovery inflammation research for small molecule programs at Amgen from target identification through preclinical assessment to IND and FIH.

The Senior Director, Small Molecule Drug Discovery in Inflammation will provide strategic, and scientific leadership across Amgen’s Inflammation Small Molecule Research portfolio, with accountability for advancing high-impact programs from early discovery through clinical and regulatory support. The Senior Director will define target- and portfolio-level strategies for small molecule modalities, including traditional small molecules, degraders, molecular glues, ADCs, and emerging chemistry-enabled approaches.

The Senior Director will serve as a senior scientific leader within Inflammation Research, representing the function across governance forums, portfolio reviews, and strategic initiatives. The role requires deep expertise in the molecular mechanisms of immunological diseases paired with experience leading matrixed teams in areas related to small molecule drug discovery including screening, medicinal chemistry, structural biology, PKDM and translational safety.

Key Responsibilities

• Through cross-functional collaboration, this Senior Director will develop integrated discovery strategies that connect target biology, molecular mechanism, and modality selecti