Senior Bioinformaticist - Gastroenterology/Hepatology

Location

SAINT LOUIS, MO 63110

Scheduled Hours

40

Position Summary

Assists in developing and conducting research projects, including experiment design, data analysis, and documentation of experiment results.

The Schwartz Laboratory in the Division of Gastroenterology, Department of Medicine, at Washington University School of Medicine in St. Louis is seeking motivated and creative scientists to join our interdisciplinary research program investigating the biology of hepatitis B virus (HBV) and the mechanisms that allow the virus to establish and maintain chronic infection. Our long-term goal is to understand the complex interactions between HBV and its host that drive viral persistence and to use these insights to identify new strategies toward a functional cure for chronic hepatitis B, which remains a major global health challenge and an important cause of liver related morbidity and mortality. Our laboratory has a strong history of developing innovative human models of viral infection. We were among the first groups to establish hepatitis B and hepatitis C virus infection models using stem cell-derived hepatocytes, and we have continued to combine these systems with primary human hepatocytes, CRISPR/Cas9 gene editing, and genetically distinct HBV clones to dissect the host and viral factors that determine infection and persistence. Recent work from the laboratory, published in Cell, identified a nucleosome-level molecular switch that primes and influences HBV infection (10.1016/j.cell.2025.01.033.

Job Description

Primary Duties & Responsibilities:

• Independently develop a wide variety of computer programs to meet the needs of data collection, quality control, analysis and report generation.

• Lead and manage research projects and work together with junior members to complete data processing and analysis following specific timelines.

• Lead complex data analysis and writes interpretative reports for Principal investigators.

• Lead and collaborate within cross-functional teams.

• Lead analytical support for internal projects and external collaborations.

• Supervise database structure: includes updating, validating, curating and harmonizing longitudinal, cross-sectional data from different sources.

• Provide a centralized, confidential and secure access to phenotypic data to Principal investigators.

• Lead the response to data queries from Principal Investigators and external collaborators.

• Create reports and prepare highly technical presentations.

• Write manuscripts and communications for conference presentations.

• Present data in meetings and conferences.

• Other duties as assigned.

Working Conditions: Job Location/Working Conditions

• Normal office environment

Physical Effort

• Typically sitting at a desk or table

Equipment

• Office equipment

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Required Qualifications

Education

• Bachelor’s degree or combination of education and/or experience may substitute for minimum education. Certifications/Professional Licenses:

• No specific certification/professional license is required for this position.

Work Experience:

• Relevant Experience (12 Years)

Skills

• Not Applicable Driver's License:

• A driver's license is not required for this position.

• More About This Job

• Preferred Qualifications

• Strong background in PLINK, QC, IBD, PCA.

• Knowledge of association analyses, PRSice, MAGENTA, Mendelian Randomization, MANTRA, Coloc, QTL and Unix/Linux.

• Preferred Qualifications

Education

• Master's degree, Ph.D. - Doctor of Philosophy Certifications/Professional Licenses:

• No additional certification/professional licenses unless stated elsewhere in the job posting. Work Experience:

• No additional work experience unless stated elsewhere in the job posting.

Skills

• Association Analysis, Bioinformatics, Biostatistics, Computational Biology, Computer Science, Docker (Software), Java (Programming Language), Linux, Linux Bash, Microsoft Excel, Perl Programming, PLINK (Software), Principal Component Analysis (PCA), Python (Programming Language), Quality Control Tools, R Programming, Scientific Programming Language, Statistical Analysis Software (SAS), Statistical Genetics, Structured Query Language (SQL), Unix Operating Systems

• Grade

• R13

• Salary Range

• $72,900.00 - $132,200.00 / Annually

• The salary range reflects base salaries paid for positions in a given job grade across the University. Individual rates within the range will be determined by factors including one's qualifications and performance, equity with others in the department, market rates for positions within the same grade and department budget.

• Questions

• For frequently asked questions about the application process, please refer to our External Applicant FAQ.

• Accommodation

• If you are unable to use our online application system and would like an accommodation, please email candidate questions or call the dedicated accommodation inquiry number.

• All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

• Pre-Employment Screening

• All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

• Benefits Statement

• Personal

• Up to 22 days of vacation, 10 recognized holidays, and sick time.

• Competitive health insurance packages with priority appointments and lower copays/coinsurance.

• Take advantage of our free Metro transit U-Pass for eligible employees.

• WashU provides eligible employees with a defined contribution (403(b)) Retirement Savings Plan, which combines employee contributions and university contributions starting at 7%.

• Wellness

• Wellness challenges, annual health screenings, mental health resources, mindfulness programs and courses, employee assistance program (EAP), financial resources, access to dietitians, and more!

• Family

• We offer 4 weeks of caregiver leave to bond with your new child. Family care resources are also available for your continued childcare needs. Need adult care? We’ve got you covered.

• WashU covers the cost of tuition for you and your family, including dependent undergraduate-level college tuition up to 100% at WashU and 40% elsewhere after seven years with us.

• For policies, detailed benefits, and eligibility, please visit: https://hr.wustl.edu/benefits/

• EEO Statement

• Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended.