Scientist LC-MS/MS Bioanalytical

About the Role Join Amgen’s mission to serve patients by designing, developing, validating, and implementing quantitative LC-MS/MS bioanalytical methods for small molecules across discovery, GLP preclinical, and regulated clinical studies. This lab-based role emphasizes independent work, data interpretation, and cross-functional collaboration to support publications, patents, and regulatory submissions.

What You'll Do

• Develop and implement LC-MS/MS bioanalytical methods with quick turnaround times for small molecule bioanalysis in matrices such as plasma, urine, CSF, and tissues.
• Conduct biological sample extraction using protein precipitation, SPE, and LLE.
• Perform bioanalysis of parent and metabolites in non-clinical and clinical samples.
• Generate complete, accurate documentation using LIMS and electronic laboratory notebook (ELN) systems.
• Support automation efforts and stay current with technology development; collaborate with teams across discovery and development; contribute to publications or regulatory submissions as appropriate.
• Prepare data presentations and communicate results to multidisciplinary teams.
• Familiarity with peptide and protein quantitation by hybrid LC-MS/MS methodology and affinity capture techniques a plus.

What We're Looking For

• Experience designing, developing, validating, and implementing quantitative LC-MS/MS bioanalytical methods for small molecules.
• Proficiency in biological sample preparation techniques including protein precipitation, SPE, and LLE.
• Familiarity with LIMS and electronic lab notebook (ELN) systems; strong documentation skills.
• Ability to interpret complex analytical data, generate clear reports, and communicate results; strong collaboration and project-management skills.
• Willingness to stay current with technology development and contribute to multidisciplinary projects including GLP preclinical and regulated clinical studies.

Nice to Have

• Familiarity with peptide and protein quantitation by hybrid LC-MS/MS methodology and affinity capture techniques.