Scientist I/II, tLNP Process Development

Job title: Scientist I/II, tLNP Process Development

About the Role The tLNP Process Development (TCT) team within Biologics CMC is seeking a scientist to advance manufacturing process development for targeted lipid nanoparticles delivering mRNA therapeutics. The role focuses on full-scale process development from purified mRNA to purified tLNP bulk drug product, including encapsulation, bioconjugation, and tangential flow filtration, with emphasis on scalable, GMP-compatible operations. The work is hands-on lab-based and involves close collaboration with mRNA process development, drug product development, analytical development and cross-functional Biologics CMC teams to optimize processes and support clinical supply and regulatory submissions.

What You'll Do

• Independently design, execute and interpret critical experiments to understand unit operations (mRNA encapsulation, bioconjugation, tangential flow filtration) and scale them to commercial manufacturing batch size.
• Highly autonomous and productive in performing laboratory research or method development, requiring minimal direction from or interaction with supervisor.
• May initiate new areas of investigation that are scientifically meaningful, reliable, and can be incorporated directly into a research or development program.
• Demonstrates high proficiency across a wide range of technologies relevant to tLNP process development.
• Formulate conclusions and design follow-on experiments based on multidisciplinary data.
• Primary author of publications, presentations, regulatory documents and/or primary inventor of patents.
• Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, and GMP compliance.

What We're Looking For

• Scientist I: BS in chemistry, colloidal science, or related field with 5+ years' industry experience or MS with 2+ years' industry experience. PhDs need not apply.
• Scientist II: BS with 7+ years' or MS with 5+ years' industry experience. PhDs need not apply.
• Industry experience in tLNP process development (mRNA encapsulation, conjugation, ultrafiltration/diafiltration) is highly preferred.
• For mRNA encapsulation, experience with systems other than microfluidics (impinging jet, coaxial jet, or multi-inlet vortex mixer) is required.
• Experience scaling up LNP processes to gram-scale mRNA or above is highly preferred.
• Possess thorough theoretical and practical understanding of mRNA encapsulation; experience with bioconjugation and lipid chemistry is a plus.
• Demonstrated ability to independently design, execute, and interpret critical experiments; ability to learn new techniques; multitask; strong scientific writing and verbal communication skills.

Nice to Have

• Experience with lipid chemistry is a plus.
• Prior experience with gram-scale mRNA LNP scale-up.
• Strong publication/patent track record.

Compensation & Benefits

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short-term incentive programs.