About this role
Job title: RESEARCH SCIENTIST
About the Role The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the core’s needs. Our core is equipped with extensive mass spectrometry instrumentation including timsTOF HT, timsTOF Ultra2 and Orbitrap Eclipse tribrid mass spectrometers. The TPD Core seeks a highly motivated individual to join the team as a RESEARCH SCIENTIST, who will employ mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli.
Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.
What You'll Do
- Lead the design and execution of proteomics experiments (eg, TMT, DIA, DDA) in collaboration with internal and external investigators
- Develop and implement automated workflows for sample preparation, instrument scheduling, data acquisition, and analysis across multiple platforms.
- Manage and maintain mass spectrometry instrumentation, including calibration, performance monitoring, and preventive maintenance to ensure high-throughput reliability.
- Integrate laboratory robotics and liquid handling systems into proteomics sample preparation pipelines to enhance throughput and reproducibility.
- Develop, optimize, and troubleshoot sample preparation workflows including whole cell proteomics, interactome analysis, and various enrichment protocols
- Analyze data using advanced pipelines (eg, DIA-NN, spectronaut, proteome discoverer) and support biological interpretation.
- Train and mentor junior staff and contribute to a culture of continuous improvement
- Ensure compliance with lab safety, QC standards, and data integrity policies
- Communicates with purchasing and may be responsible for negotiating with vendors
What We're Looking For
- Ph.D in biochemistry, analytical chemistry, bioengineering or related field.
- Strong expertise in mass spectrometry-based proteomics and data analysis
- Hands on experience operating Thermo and/or Bruker mass spectrometers is required
- Demonstrated experience with laboratory automation, robotics, or pipeline development (e.g., Hamilton, Opentrons, or custom scripting for workflow automation).
- Proficiency with quantitative proteomics (label-free, TMT, DIA) and enrichment techniques.
- Familiarity with data analysis software and scripting (DIA-NN, Proteome Discoverer, R, Python).
- Excellent organizational, troubleshooting, and communication skills.
- Proven ability to work collaboratively across interdisciplinary teams and manage multiple projects simultaneously.
- License/Certification/Registration Required: None
Nice to Have
- Strong emphasis on instrument automation, systems management, and proteomics pipeline development is highly desirable.
Compensation & Benefits
- Salary range: $80,000.00 - $95,900.00 per year