About this role
The Therapeutics Research group at Moderna is seeking a talented, experienced, and highly motivated Principal Scientist to build, optimize, and execute T cell receptor optimization workflows for next-generation TCR-based therapeutics.
This individual will lead the development of scalable experimental platforms to improve key TCR properties, including affinity, cross-reactivity, stability, expression, developability, functional potency, and compatibility with mRNA-expressed therapeutic formats. The successful candidate will apply deep expertise in display-based protein engineering, TCR biology, biophysical characterization, cross-reactivity screning, and functional assays to advance TCR candidates through iterative wet-lab and computational optimization.
This candidate will work closely with cross-functional partners in TCR discovery, protein engineering, computational biology, AI/ML, functional assay development, translational science, and preclinical development. The role is well suited for a hands-on scientist who can execute complex experimental workflows, interpret multi-parameter datasets, and contribute to the generation of optimized TCR candidates with the potency, specificity, and developability required for therapeu