About this role
About the Role Moderna is seeking an individual to provide technical leadership for in vitro selection and cell-surface screening of viral and bacterial antigens. This role will lead the design, execution, and advancement of high-throughput mammalian cell–based screening platforms to interrogate design principles for glycoprotein antigens, enabling antigen optimization and rapid maturation of computationally designed candidates. The candidate will own and evolve a core discovery capability and collaborate with computational design teams across Moderna’s pipeline. What You'll Do
- Lead execution of in vitro selection and cell-surface screening campaigns, providing technical leadership through direct involvement in experimental design and execution.
- Design and run high-throughput mammalian display campaigns for complex, multimeric glycoproteins.
- Build and deploy scalable screening systems that replace resource-intensive plate-based assays.
- Develop and operationalize advanced in vitro selection and directed-evolution capabilities, including novel selection pressures and expanded mammalian display modalities.
- Serve as a key experimental partner to computational protein design teams, generating high-quality datasets and actionable design feedback.
- Provide technical mentorship and scientific guidance to other scientists.
- Represent in vitro selection capabilities in cross-functional discovery and platform discussions.
- Mentor and technically guide junior scientists to elevate overall design quality. What We're Looking For
- PhD in Immunology, Molecular Biology, Biochemistry, Protein Engineering, or a related field.
- 5+ years of post-PhD industry or equivalent experience.