About this role
Principal Scientist, Computational Protein Design
locations
Cambridge, Massachusetts
Research
time type
Full time
posted on
Posted Today
job requisition id
R19575
The Role: Moderna’s Therapeutics Research group is seeking a talented, experienced, and highly motivated Principal Scientist to support computational protein design across therapeutic research. This role will focus primarily on the design and optimization of T cell receptors and antibodies, while also contributing to broader protein design efforts across a range of therapeutic modalities.
The successful candidate will bring deep expertise in protein structure, de novo binder design, molecular recognition, and state-of-the-art computational design methods and workflows. They will serve as a scientific and technical leader for computational binder design, helping to build a next-generation platform for the discovery, engineering, and optimization of TCRs and antibodies against defined targets. This individual will work in close partnership with structural biology, directed evolution, immunology, translational science, and program teams to advance platform innovation and therapeutic programs across Moderna’s Research and Early Development portfolio.
Here’s What You’ll Do
Lead and execute computational protein design campaigns across therapeutic research, with a focus on de novo binder design for TCRs and antib