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Principal Analyst, Project Portfolio Management Technology

Vertex Pharmaceuticals Incorporated
Boston, MA Posted Sep 15, 2026
Full-time

About this role

Job Title: Principal Analyst, Project Portfolio Management Technology

Job Description

General Summary:

The Business Engagement & Technology Principal Analyst will be a technical resource in ensuring delivery and support of commercial-off-the-shelf (COTS) and a wide range of custom solutions in support of their business partners. The Business Engagement & Technology Principal Analyst will partner with business leadership to deliver capabilities and execute on a roadmap that align to support business strategy. Additionally, the Business Engagement & Technology Principal Analyst will maintain reliable, scalable and compliant systems that easily meet business needs by efficient delivery and enhancements that provides opportunities for developing and implementing innovative solutions and integrations.

Key Duties and Responsibilities:

  • Become a trusted partner of the business leaders within their remit
  • Understand their needs and vision, and deliver technology solutions to support and enable their goals and objectives
  • Provide insights on how technology can improve business processes to enable operating efficiencies and support the achievement of business goals and objectives
  • Help refine and execute the technology strategy by leading the evaluation, selection, implementation, and ongoing maintenance of technology solutions
  • Develop and maintain a long term life cycle plan for the ongoing maintenance and management of systems
  • Manage relationships with our strategic software vendors and service providers
  • Work closely with DTE Compliance, Internal Audit, and Quality Assurance groups as needed to ensure compliance with all appropriate regulations, as well as our DTE system lifecycle and change management requirements

Knowledge and Skills:

  • In-depth knowledge in the core disciplines of project management, business analysis, solution design, delivery, and testing
  • Experienced in building productive partnerships with business stakeholders and aligning them around a recommendation/solution
  • Strong understanding of the business, processes, and any appropriate regulatory environments
  • Results oriented contributor with a proven track record of on-time project delivery for large, complex projects with global stakeholders
  • Able to manage own workload with minimal direction
  • Very strong written and verbal communication skills and strong ability to present complex or sensitive information in a clear and concise manner to various technical and non-technical audiences
  • Exceptional analytical, quantitative, problem-solving, and prioritization skills
  • Strong system life cycle expertise
  • Good knowledge of running IT managed services or outsourced/ offshore teams
  • Very strong MS Office skills, including MS Project Server & Visio, Excel and PowerPoint experience
  • Experience in Agile methodology

Education and Experience:

  • Bachelor's degree in technology discipline or equivalent
  • 6 years relevant business systems in the Life Sciences industry, or the equivalent combination of education and experience

At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Flex Designation:

Hybrid-Eligible Or On-Site Eligible

Flex Eligibility Status:

In this Hybrid-Eligible role, you can choose to be designated as:

  1. Hybrid: work remotely up to two days per week; or select
  2. On-Site: work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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