Precision Medicine Global Biomarker Lead, Rare Disease

Job title: Precision Medicine Global Biomarker Lead, Rare Disease

About the Role In this vital role within Amgen’s Precision Medicine Unit, the Global Biomarker Lead will be a key member of Amgen’s cross-functional product teams, driving biomarker strategies that align with Precision Medicine goals. The successful candidate will be an experienced senior principal scientist with expertise in clinical biomarker research and drug development in rare diseases and/or autoimmunity and inflammation, developing and executing robust precision medicine strategies integrated with global development plans. The role includes overseeing assay readiness, vendor management, and interpretation of biomarker data generation, while partnering closely with clinical development, research, and medical affairs colleagues.

What You'll Do

• Lead the development and execution of program-specific clinical biomarker strategies to inform target engagement, pharmacodynamics, mechanism of action, and patient selection across early and late-stage programs.
• Serve as precision medicine subject matter expert within product evidence generation teams to deliver precision medicine and translational medicine approaches to enable strategic alignment and delivery of high-quality biomarker datasets.
• Responsible for biomarker elements in clinical protocols, biomarker analysis plans, regulatory submissions, investigator meetings, advisory boards and publications.
• Lead and partner with biomarker technical sub-teams to plan all biomarker-related activities across development programs.
• Partner closely with clinical development, research, and medical affairs colleagues to ensure biomarker data informs development decisions.

What We're Looking For

• Highly motivated and experienced senior principal scientist with expertise in clinical biomarker research and drug development in rare diseases and/or autoimmunity and inflammation.
• Ability to develop and execute scientifically robust precision medicine strategies integrated with global development strategies.
• Experience overseeing assay readiness, vendor management, and interpretation of biomarker data generation; partnering with clinical development, research, and medical affairs.
• Knowledge of biomarker elements in clinical protocols, biomarker analysis plans, regulatory submissions, investigator meetings, advisory boards and publications.
• Strong collaboration and communication skills to work across cross-functional teams.