High Throughput Biology Research Scientist

High Throughput Biology Research Scientist

Job Description

Role Summary

The High Throughput Human Biology group is seeking a highly motivated Research Scientist to support discovery programs through the development and implementation of innovative human biology assays. Working in a collaborative, multidisciplinary environment, the successful candidate will draw on expertise in cellular and molecular biology, laboratory automation, and data analysis to develop in vitro assays spanning multiple levels of biological complexity and define their application within high-throughput screening strategies. The successful candidate will also evaluate and incorporate emerging technologies, establish scalable experimental workflows, and partner across disciplines to translate scientific needs into robust solutions. They will leverage AI-enabled tools to improve workflow efficiency, accelerate experimental iteration, and support data-driven project decisions.

The ideal candidate will bring strong hands-on laboratory skills, scientific and technical creativity, and the ability to independently advance projects from concept through implementation.

Key Responsibilities

• Develop, optimize, and implement high-throughput human biology assays to address key questions or challenges in discovery biology across multiple programs

• Build integrated automation workflows for cellular and biochemical assays leveraging robotics, high-throughput liquid handling, and custom computational solutions

• Execute screening and follow-up studies, analyze complex datasets, and translate findings into actionable recommendations for project teams

• Troubleshoot assay and automation performance and drive continuous improvements in throughput, data quality, and operational reliability

• Identify unmet scientific needs relevant to our research areas and develop solutions from conceptualization through prototyping and implementation

• Evaluate emerging technologies and apply promising solutions to internal programs

• Represent the High Throughput Human Biology group as part of highly collaborative, interdisciplinary teams, communicate results clearly and maintain rigorous, reproducible records

• Required Qualifications

• PhD in a relevant scientific discipline with 0-3 years of relevant experience

• Scientifically curious, driven and independent, motivated by making impact to project progression

• Demonstrated creativity in biological assay development

• Foundational molecular biology and cell biology laboratory experience in multi-well plate formats, including complex human cellular assays, immunoassays, qPCR, high-content imaging, and other relevant functional and target engagement assays

• Proficiency in relevant coding languages, such as Python, R or MATLAB

• Proven track record of success working in collaborative, multi-disciplinary teams

• Excellent written and verbal communication skills

• Preferred Qualifications

• Hands-on experience with laboratory automation, automated liquid handling, or integrated instrumentation strongly preferred

• Experience developing or deploying AI-enabled scientific and computational workflows strongly preferred

• A record of building and applying useful tools, prototypes, methods, or process improvements

• Ability to multi-task and prioritize effectively across involvement in multiple projects

• At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

Pay Range:

• $105,600 - $158,400

Disclosure Statement:

• The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

• At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:

• On-Site Designated

Flex Eligibility Status:

• In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]

About Vertex

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases and conditions. The company has approved therapies for cystic fibrosis, sickle cell disease, transfusion-dependent beta thalassemia, acute pain and acromegaly, and it continues to advance clinical and research programs in these areas. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including IgA nephropathy, neuropathic pain, APOL1-mediated kidney disease, primary membranous nephropathy, congenital adrenal hyperplasia, ACTH-dependent Cushing's syndrome, autosomal dominant polycystic kidney disease, type 1 diabetes, generalized myasthenia gravis, and myotonic dystrophy type 1.

Vertex was founded in 1989 and has its global headquarters in Boston, with international headquarters in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 16 consecutive years on Science magazine's Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex's history of innovation, visit www.vrtx.com or follow us on LinkedIn, Facebook, Instagram, YouTube, and X

We believe our culture is one of Vertex’s greatest strengths and a key enabler of our ability to deliver transformative medicines for patients who need them. Rooted in innovation, purpose and collaboration, our culture empowers people to take smart risks, challenge conventional thinking and do their best work. The diversity of our people is central to that culture. By bringing together individuals with different backgrounds, experiences and perspectives, we foster an environment where new ideas thrive, better decisions are made and breakthrough innovation is possible. We are committed to creating a workplace where everyone feels valued, included and connected to our shared mission, because we know that our unique culture and the collective strength of our people are what set Vertex apart.

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