Feasibility Principal Analyst - Home-Based (US)

About the Role Feasibility Principal Analyst leads study-level feasibility strategy within ICON's Patient and Site Engagement (PSE) team, supporting the acceleration of clinical studies across rare disease programs. Reporting to the Director of Feasibility, this role translates complex operational and enrollment data into clear, data-driven recommendations and mentors junior team members in a fast-paced environment. What You'll Do

• Lead feasibility activities for assigned clinical studies under the strategic guidance of the PSE Director or Associate Director.
• Drive feasibility strategy and execution at the study level, optimizing trials and delivering milestones in alignment with program objectives and feasibility standards.
• Synthesize and analyze feasibility, operational, and enrollment data from multiple sources to build a deep understanding of therapeutic areas, standard of care, disease progression, patient/site profiles, and competitive landscape.
• Apply advanced data mining and analytical approaches, including complex enrollment modeling and forecasting, to generate data-driven enrollment assumptions, risk assessments, and strategic recommendations.
• Thrive in a fast-paced study environment, rapidly reprioritizing and adjusting feasibility approaches to meet tight timelines.
• Manage multiple studies and last-minute requests with strong time management while maintaining analytical rigor and clear communication.
• Partner with cross-functional study teams, communicating insights, assumptions, risks, and recommendations to support study planning, site selection, and enrollment strategy decisions.
• Deliver data-driven presentations to cross-functional teams and governance forums, addressing questions from senior leadership as needed.
• Mentor junior feasibility team members, advancing analytical skills and consistency in deliverables.
• Apply operational judgment and clinical trial expertise to proactively identify challenges, anticipate risks, and drive solutions.
• Contribute to continuous improvement of feasibility processes, tools, and best practices by sharing lessons learned. What We're Looking For
• Bachelor’s degree in a scientific or allied health field (or equivalent industry experience) with 7+ years of progressive experience in clinical research, feasibility, clinical operations, or study startup within a sponsor or CRO.
• Minimum of 5 years of hands-on operational feasibility experience supporting complex studies or programs.
• Demonstrated track record leading feasibility strategy for complex studies or programs with influence on site selection, enrollment strategy, and study acceleration.
• Experience across multiple therapeutic areas or late-phase programs with increasing strategic accountability.
• Proven ability to analyze, synthesize, and interpret complex feasibility, operational, and enrollment data and translate findings into clear insights and actionable recommendations.
• Advanced proficiency in Excel and other data-driven analysis tools; experience structuring, analyzing, and presenting data for feasibility assessments, benchmarking, and enrollment forecasting.
• Strong verbal and written communication skills with the ability to present complex, data-driven analyses to diverse stakeholders.
• Demonstrated critical thinking and solution-oriented, creative problem-solving skills. Compensation & Benefits
• Competitive salary; benefits designed to support well-being and work-life balance.
• Various annual leave entitlements and range of health insurance offerings.
• Competitive retirement planning offerings.
• Global Employee Assistance Programme (LifeWorks) with 24/7 access to a global network of professionals.
• Life assurance and flexible country-specific optional benefits (childcare vouchers, bike purchase schemes, discounted gym memberships, subsidized travel passes, health assessments, etc.).
• ICON is committed to inclusion and equal opportunity for all applicants.