Principal Scientist
About this role
Job title: Principal Scientist
About the Role
The Genomic Medicine Unit CMC group at Sanofi is focused on establishing best-in-class manufacturing platforms to support development of life-changing cell and gene therapy products. The Senior Scientist will operate within the Upstream Scale-Up Laboratory in Waltham, MA, executing cell culture bioprocesses at pilot and manufacturing scales (200L–2000L) and translating bench-scale learnings into robust, scalable processes. This is an embedded, technically focused role with no direct people management responsibilities, emphasizing technical leadership and SME-level upstream bioprocessing expertise.
What You'll Do
- Lead scale-up activities from bench scale to pilot scale (200L–2000L), applying engineering principles (mixing, mass transfer, shear stress, dissolved oxygen control) to ensure process comparability at large scale.
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